Category: Analgesic & Antipyretic • Catalog ID: CROCIN-500 • Reviewed by MediMatch Clinical Pharmacology Review Board

Crocin 500 Tablet — Paracetamol (Acetaminophen) 500mg

Evidence-based clinical monograph for Crocin 500 Tablet, formulated with active pharmaceutical ingredient Paracetamol (Acetaminophen) 500mg and manufactured by GlaxoSmithKline Pharmaceuticals. Includes FDA/EMA/WHO international nomenclature cross-walk, 6-point patient safety matrix, and multi-currency generic reference pricing.

1. Quick Facts & Global Nomenclature Cross-Walk (WHO INN / US FDA USAN / UK BNF)

Brand Name	Crocin 500 (Tablet)
Active Salt (WHO INN)	Paracetamol (WHO INN)
U.S. FDA USAN / Orange Book	Acetaminophen (USP / FDA Orange Book)
UK BNF / EMA BAN	Paracetamol (BP / Ph. Eur.)
Global Commercial Brand Equivalents by Region	🇺🇸 USA/Canada: Tylenol 500mg / FeverAll (Tylenol Extra Strength) • 🇬🇧 UK/Europe: Panadol Advance / Efferalgan • 🇦🇺 Australia: Panadol Optizorb (TGA) • 🇦🇪 UAE/GCC: Panadol / Adol 500mg (MOHAP) • 🇮🇳 India: Crocin 500 / Crocin / Dolo 650
Same-Salt Commercial Brand Substitutes	Crocin 500Calpol 500Dolo 500Metacin 500Pyregesic 500
Dosage Form & Route	Tablet (Oral Systemic Administration)
Manufacturer	GlaxoSmithKline Pharmaceuticals
Branded MRP vs Jan Aushadhi Generic	MRP ₹22.00 vs Jan Aushadhi ₹4.20 • Save ₹17.80 (81% Off)

2. 6-Point Clinical Safety Profile (Pregnancy, Lactation, Alcohol, Driving, Renal & Hepatic)

Clinical pharmacology safety verification for Crocin 500 Tablet (Paracetamol (Acetaminophen) 500mg) across special patient populations:

Safety Parameter	Clinical Status Badge	Pharmacological Guidance & Precaution
Pregnancy (FDA PLLR / TGA)	SAFE	Considered first-line antipyretic/analgesic across pregnancy trimesters at lowest effective dose for shortest duration (FDA PLLR / TGA Cat A).
Breastfeeding (Lactation)	SAFE	Compatible with breastfeeding; less than 2% of maternal dose appears in breast milk.
Alcohol Interaction	AVOID	Strictly avoid chronic or heavy alcohol use due to CYP2E1 induction and heightened acute hepatotoxicity risk (max 4,000 mg/day).
Driving & Alertness	SAFE	Generally does not impair psychomotor alertness at standard doses; avoid driving if dizziness or fatigue occurs.
Kidney (Renal Dosing)	CAUTION — CONSULT DOCTOR	Dose interval adjustment may be required in moderate-to-severe renal impairment (eGFR < 30 mL/min/1.73m²).
Liver (Hepatic Dosing)	AVOID	Contraindicated in severe hepatic failure or active liver disease; restrict max daily dose to <= 2,000 mg in mild hepatic impairment.

3. Clinical Indications, Mechanism of Action & Pharmacokinetics

Crocin 500 (Tablet) containing Paracetamol (Acetaminophen) 500mg is clinically indicated for the management and treatment of:

Fever: Targeted therapeutic efficacy via Analgesic & Antipyretic pathway modulation.
Mild headache: Targeted therapeutic efficacy via Analgesic & Antipyretic pathway modulation.
Toothache: Targeted therapeutic efficacy via Analgesic & Antipyretic pathway modulation.
Cold & flu bodyache: Targeted therapeutic efficacy via Analgesic & Antipyretic pathway modulation.

Mechanism of Action & Pharmacokinetics: Following administration as a tablet, Paracetamol (Acetaminophen) 500mg undergoes calibrated systemic absorption and hepatic/renal clearance in accordance with WHO-GMP, USP, and Indian Pharmacopoeia (IP) dissolution and bioequivalence standards.

4. Standard Dosage Table, Administration & Storage Guidelines

Dosage & Administration Reference Table: Always follow your physician's prescription for Crocin 500 Tablet (ISMP safety normalized):

Prescription Sig Code	Administration Schedule	Meal & Timing Guidance	Clinical Patient Group
OD (Once Daily)	1 unit (Tablet) every 24 hours	After food	Adults & Children > 6 yrs
BD / BID (Twice Daily)	1 unit (Tablet) every 12 hours (Morning & Night)	After food	Adults & Children > 6 yrs
TDS / TID (Thrice Daily)	1 unit (Tablet) every 8 hours (if prescribed)	Maintain minimum 6–8 hour spacing	As directed by registered physician

Storage & Stability: Store Crocin 500 (Tablet) in a cool, dry place below 30°C (86°F) away from direct sunlight, heat, and moisture. Keep blister strips sealed until administration and out of reach of children.

5. Side Effects, Contraindications & Drug-Drug Interactions

Potential adverse reactions reported with Crocin 500 Tablet (Paracetamol (Acetaminophen) 500mg):

Nausea
Stomach discomfort

Contraindications & Clinical Safety Precautions:

Keep out of reach of children
Do not combine with other paracetamol products
Contraindicated in patients with known hypersensitivity to Paracetamol (Acetaminophen) 500mg or any excipient of Crocin 500 Tablet.
Verify active salt (Paracetamol (Acetaminophen) 500mg) before co-administering other OTC or prescription medicines to avoid accidental therapeutic duplication.

Dolo 650 vs Crocin 500 Dolo 650 vs Paracetamol Pantocid 40 vs Omez 20 Augmentin 625 vs Moxikind-CV 625

Check Drug-Food Interactions Check Multi-Drug Interactions

6. PMBJP Jan Aushadhi Generic Comparison Table & Multi-Currency Reference Price

Bioequivalent generic Paracetamol (Acetaminophen) 500mg (Tablet) is available across global public formularies and at NABL-certified PMBJP Jan Aushadhi Kendras in India for ₹4.20 — saving ₹17.80 (81%) compared to Crocin 500 by GlaxoSmithKline Pharmaceuticals at ₹22.00.

Region & Formulary Tariff	Currency	Branded Originator Reference	Verified Bioequivalent Generic Price
🇮🇳 India Jan Aushadhi (₹ INR) — PMBJP / NPPA	`₹ INR`	₹22.00 (Crocin 500)	₹4.20 (81% Savings)
🇺🇸 US FDA Generic ($ USD) — CMS NADAC / Orange Book	`$ USD`	$7.70	$1.20 (AB-Rated Generic)
🇬🇧 UK NHS Tariff (£ GBP) — Drug Tariff / BNF	`£ GBP`	£5.72	£0.95 (NHS Category M/A)
🇪🇺 EU EMA Generic (€ EUR) — EMA Reference Tariff	`€ EUR`	€6.38	€1.10 (EMA Bioequivalent)
🇦🇺 Australia PBS (A$ AUD) — TGA Dispensed Tariff	`A$ AUD`	A$9.90	A$1.85 (PBS Listed Generic)

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Global Multilingual Patient Guide — Español • Français • العربية • हिन्दी

🌐 English (EN) — Clinical Patient Summary

Crocin 500 (Tablet) contains active ingredient Paracetamol (Acetaminophen) 500mg. Indicated for: Fever, Mild headache. Pregnancy status: SAFE. Avoid alcohol and verify bioequivalent generics with your pharmacist.

🇪🇸 Español (ES): ¿Para qué sirve Crocin 500 (Paracetamol (Acetaminophen) 500mg), dosis y efectos secundarios?

Crocin 500 (Tablet) contiene Paracetamol (Acetaminophen) 500mg. Indicado para: Fever, Mild headache. Embarazo: SAFE. Evite el alcohol y consulte a su médico o farmacéutico para equivalentes genéricos bioequivalentes.

🇫🇷 Français (FR): Indications, posologie et effets secondaires de Crocin 500 (Paracetamol (Acetaminophen) 500mg)

Crocin 500 (Tablet) contient le principe actif Paracetamol (Acetaminophen) 500mg. Utilisé pour : Fever, Mild headache. Grossesse : SAFE. Demandez le générique bioéquivalent (DCI) en pharmacie.

🇦🇪 العربية (AR): دواعي استعمال Crocin 500 والجرعة والآثار الجانبية

يحتوي دواء Crocin 500 (Tablet) على المادة الفعالة Paracetamol (Acetaminophen) 500mg. يستخدم لعلاج الحالات السريرية الموصوفة. يرجى استشارة الطبيب أو الصيدلي للتحقق من الجرعة والبدائل الجنيسة المعتمدة.

🇮🇳 हिन्दी / Hinglish (HI): Crocin 500 के उपयोग, खुराक और साइड इफेक्ट्स (Crocin 500 Uses in Hindi)

Crocin 500 (Tablet) में मुख्य साल्ट Paracetamol (Acetaminophen) 500mg है। प्रधानमंत्री भारतीय जनऔषधि केंद्र (PMBJP) पर इसका समान असर वाला जेनेरिक विकल्प मात्र ₹4.20 (81% बचत) में उपलब्ध है।

8. Frequently Asked Questions (Crocin 500 Tablet)

Q: What is Crocin 500 Tablet (Paracetamol (Acetaminophen) 500mg) used for?

Crocin 500 Tablet contains Paracetamol (Acetaminophen) 500mg and is manufactured by GlaxoSmithKline Pharmaceuticals. It is primarily indicated for Fever, Mild headache, Toothache, Cold & flu bodyache under the Analgesic & Antipyretic therapeutic class.

Q: Is a generic equivalent or Jan Aushadhi substitute available for Crocin 500 Tablet?

Yes, bioequivalent generic Paracetamol (Acetaminophen) 500mg (Tablet) is available globally ($1.20 USD NADAC / £0.95 UK NHS Tariff) and at PMBJP Jan Aushadhi Kendras in India for ₹4.20 per strip, saving 81% compared to branded MRP ₹22.00.

Q: What is the dosage instruction for Crocin 500 Tablet?

Common dosage frequencies for Crocin 500 (Tablet) are OD (once daily), BD/BID (twice daily), or TDS/TID (thrice daily) as prescribed by your physician. After food

Q: Is Crocin 500 Tablet safe during pregnancy, breastfeeding, or with alcohol?

Pregnancy guidance: SAFE (Considered first-line antipyretic/analgesic across pregnancy trimesters at lowest effective dose for shortest duration (FDA PLLR / TGA Cat A).) Alcohol guidance: AVOID (Strictly avoid chronic or heavy alcohol use due to CYP2E1 induction and heightened acute hepatotoxicity risk (max 4,000 mg/day).)