Pan-D vs Omez-D: Composition, Uses, Side Effects & Generic Savings
Compare Pan-D and Omez-D for acidity, GERD, and nausea. Understand differences between Pantoprazole vs Omeprazole combinations with Domperidone and...
Pan-D contains Pantoprazole (40mg) + Domperidone (30mg SR), while Omez-D contains Omeprazole (20mg) + Domperidone (10mg or 30mg SR). Both treat GERD, acid reflux, and nausea. Pantoprazole in Pan-D has fewer cytochrome P450 drug interactions, making it preferred for patients taking other cardiovascular or diabetes medicines.
1. Active Pharmaceutical Ingredients (API) Comparison
Pan-D combines Pantoprazole 40mg with Domperidone 30mg Sustained Release. Omez-D typically contains Omeprazole 20mg with Domperidone. Both drugs combine a Proton Pump Inhibitor (PPI) which shuts down acid-producing pumps in the stomach lining, with a prokinetic agent (Domperidone) which prevents nausea and accelerates gastric emptying.
2. Dosing Schedule & Timing Rules
Both Pan-D and Omez-D must be swallowed whole with water 30 to 60 minutes BEFORE morning breakfast. Taking them after food reduces their acid-suppression effectiveness by more than 50%. Do not crush or chew the capsules, as the enteric coating protects the active drugs from acidic degradation in the stomach before reaching the intestine.
3. Jan Aushadhi Generic Savings
Branded Pan-D costs approximately ₹199 per strip of 15 capsules. Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), bioequivalent Pantoprazole 40mg + Domperidone 30mg SR capsules are available at Jan Aushadhi Kendras for approximately ₹22 per strip of 10 capsules—providing up to 88% consumer savings with verified bioequivalence.
4. Safety Warnings & Cardiovascular Caution
Domperidone has a known risk of prolonging the QT interval on an electrocardiogram (ECG) when taken in high doses or combined with certain antibiotics (such as erythromycin) or antifungals (such as fluconazole). Patients with heart conditions should always have their prescription reviewed by a cardiologist.
Top 8 Essential Indian Medicines: Branded MRP vs. Jan Aushadhi Generic Comparison
Compare average Indian retail MRP of top branded formulations against government-certified PMBJP Jan Aushadhi bioequivalent generic prices and active salts. Verified against official PMBJP formularies, NPPA price caps, and CDSCO regulatory registries.
| Brand Name | Leading Manufacturer | Active Salt Formulation (IP) | Branded MRP | Jan Aushadhi Price | Savings % |
|---|---|---|---|---|---|
| Augmentin 625 Duo | GlaxoSmithKline Pharmaceuticals | Amoxicillin Trihydrate 500mg + Potassium Clavulanate 125mg IP | ₹220.00 | ₹58.00 | 74% |
| Dolo 650 | Micro Labs Ltd | Paracetamol (Acetaminophen) 650mg IP | ₹34.00 | ₹5.50 | 84% |
| Pantocid 40 | Sun Pharmaceutical Industries | Pantoprazole Sodium 40mg IP (Gastro-resistant) | ₹155.00 | ₹8.00 | 95% |
| Azithral 500 | Alembic Pharmaceuticals | Azithromycin Dihydrate 500mg IP | ₹132.00 | ₹24.00 | 82% |
| Glycomet 500 | USV Private Limited | Metformin Hydrochloride 500mg IP | ₹24.00 | ₹4.50 | 81% |
| Shelcal 500 | Torrent Pharmaceuticals | Elemental Calcium 500mg + Cholecalciferol (Vit D3) 250 IU IP | ₹134.00 | ₹16.00 | 88% |
| Telma 40 | Glenmark Pharmaceuticals | Telmisartan 40mg IP | ₹92.00 | ₹7.50 | 92% |
| Montair-LC | Cipla Ltd | Montelukast Sodium 10mg + Levocetirizine Dihydrochloride 5mg IP | ₹210.00 | ₹18.00 | 91% |
| Combined 8-Drug Essential Therapy Basket Total: | ₹1,001.00 | ₹141.00 | 85.9% Net Savings | ||
Frequently Asked Questions (Clinical & Regulatory)
Q1: Which is stronger, Pan-D or Omez-D?
Pan-D contains 40mg of Pantoprazole, providing longer and more stable acid suppression with fewer drug interactions than 20mg Omeprazole in Omez-D.
Q2: Can I take Pan-D twice a day?
Standard dosing is once daily before morning breakfast. In severe erosive GERD, a physician may prescribe a second dose 30 minutes before dinner for a short duration.
Q3: What is the optimal timing for taking Proton Pump Inhibitors (Pantoprazole, Omeprazole)?
Proton Pump Inhibitors (PPIs) must be administered 30 to 60 minutes before the morning meal with plain water. PPIs are prodrugs that require actively secreting H+/K+ ATPase proton pumps—stimulated by food anticipation—to achieve irreversible covalent enzyme suppression.
Q4: Are PMBJP generic PPIs bioequivalent to branded antacids like Pantocid 40 or Omez?
Yes. PMBJP Jan Aushadhi gastro-resistant pantoprazole and omeprazole tablets are formulated in WHO-GMP certified facilities with enteric polymers that protect the active drug from gastric acid degradation, matching innovator dissolution and bioavailability profiles at up to 95% patient savings.
Q5: Can antacid syrups be taken simultaneously with oral antibiotics or thyroid tablets?
No. Antacid suspensions containing aluminum hydroxide, magnesium hydroxide, or calcium carbonate chelate antibiotics (ciprofloxacin, doxycycline) and levothyroxine in the gastrointestinal tract, reducing systemic drug absorption by 50% to 75%. Maintain a strict 2-hour interval.
This clinical guide is authored and reviewed in accordance with the regulatory standards of the Indian Pharmacopoeia (IP), Central Drugs Standard Control Organization (CDSCO) drug schedules, and Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP) bioequivalence guidelines. All therapeutic recommendations and drug interaction warnings are cross-referenced with official statutory publications.
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