Pan 40 vs Pan-D — Clinical Comparison & Jan Aushadhi Generic Savings
Compare Pan 40 (Pantoprazole 40mg) vs Pan-D (Pantoprazole 40mg + Domperidone 30mg SR). Composition, acid vs nausea indications, timing, and Jan Aushadhi generic alternatives.
Executive Clinical Summary
Both manufactured by Alkem Laboratories, Pan 40 and Pan-D are household names in Indian gastrointestinal medicine. The key distinction lies in the addition of Domperidone in Pan-D to address motility symptoms.
Pan 40 provides pure acid inhibition through gastric parietal cell H+/K+ ATPase blockade. Pan-D combines this with Domperidone 30mg SR to stimulate gastrointestinal motility and accelerate stomach emptying.
Side-by-Side Pharmacological Comparison Table
| Parameter | Pan 40 | Pan-D |
|---|---|---|
| Active Salt Composition | Pantoprazole Sodium IP 40mg | Pantoprazole Sodium IP 40mg + Domperidone IP 30mg SR |
| Therapeutic Class | Proton Pump Inhibitor (PPI) | PPI + Prokinetic Dopamine Antagonist FDC |
| Primary Indication | Gastric acid reduction, heartburn, peptic ulcers | Acid reflux with nausea, bloating, delayed gastric emptying |
| Administration Window | 30–60 min before breakfast (Empty stomach) | 30–60 min before breakfast (Empty stomach) |
| CDSCO Regulatory Schedule | Schedule H Prescription Drug | Schedule H Prescription Drug |
PMBJP Jan Aushadhi Generic Cost Advantage
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana, bioequivalent generic alternatives of both Pantoprazole plain and Pantoprazole + Domperidone SR are available at government Jan Aushadhi kendras across India. Switching to verified PMBJP generic formulations reduces out-of-pocket medication expenses by up to 84% without any reduction in pharmacological bioavailability. Always seek medical guidance before changing branded regimens.
Frequently Asked Questions (Clinical FAQs)
Q1: What is the main difference between Pan 40 and Pan-D?
Pan 40 contains only Pantoprazole (40mg). Pan-D contains Pantoprazole (40mg) plus Domperidone (30mg SR) to treat nausea and improve stomach movement.
Q2: When should I take Pan-D instead of Pan 40?
Take Pan-D if your doctor diagnosed acid reflux with nausea, vomiting, or stomach heaviness. For simple acidity without nausea, Pan 40 is typically preferred.